ABSTRACT
AIM:To study and compare the outcomes of coaxial 2. 2 mm phacoemulsiflcation with conventional coaxial 3 mm small-incision cataract surgery. METHODS: A randomized prospective study was conducted on 100 patients with age - related cataract:coaxial 2. 2 mm micro - incision cataract surgery was performed in 50 cases (50 eyes), and coaxial 3 mm small incision cataract surgery was performed in 50 cases ( 50 eyes) . Statistical analysis was takenwith the data of the two groups. Visual acuity, VF and QOL were compared at intervals of 1wk and 3mo after surgery. In addition, surgically induced astigmatism ( SIA ) was analyzed. Statistic analysis was taken by Student's t-test and Chi-square test. RESULTS:There was no significant difference on BCVA (t=-1. 366, -1. 688; P=0. 148, 0. 107) between these two groups. One week and 3mo after the surgery, SIA was (0. 46±0.29)D, (0. 43±0. 26)D in the 2. 2 group; and (1. 55±0. 59) D, (0. 89±0. 28) D, in 3. 0 group. The differences between these two groups were statistically significant ( t=-7. 348, -3. 788; P = 0. 000, 0. 000 ) There were no statistically significant differences on VF scores between two group, while it's got a better score in 2. 2 groups on vision adaptation. (t=-3. 348, P CONCLUSION:Coaxial 2. 2mm micro-incision cataract surgery could significantly reduce SIA and obtain morestable status of VF and QOL. This suggests that the coaxial 2. 2 phacoemulsification surgery implanted AkreosMI60 intraocular lens could get earliervisual rehabilitation postoperation.
ABSTRACT
Objective: To observe the changes in the anatomy of anterior segment before and after phacoemulsification for treatment of angle-closure glaucoma by Pentacam system, so as to assess the efficacy of phacoemulsification combined with artificial lens implantation(ALI) in treatment of early- and middle-stage angle-closure glaucoma. Methods: Forty-two patients with early- and middle-stage angle-closure glaucoma(44 eyes) were included in the present study. The central anterior chamber depth, anterior chamber volume and peripheral anterior chamber angle were examined by Pentacam system pre-operatively and 1 day, 1 week and 3 months post operatively. Meanwhile, A ultrasound was used to examine the anterior chamber depth before and 3 months after operation, and the results were compared with those by Pentacam system. Results: Pentacam system could clearly demonstrate the 3-dimensional structures of the anterior eye segment before and after operation. The central anterior chamber depth, anterior chamber volume and anterior chamber angle were increased significantly after operation(P<0.01); the intraocular pressure was significantly decreased(P<0.01); and the visual acuity was improved(P<0.01). The values of central anterior chamber depth and the dispersion coefficient obtained by Pentacam were smaller than those by A ultrasound. Conclusion: Pentacam system can directly demonstrate the increase of anterior chamber depth, anterior chamber volume, and anterior chamber angle after phacoemulsification combined with ALI in treatment of early- and middle-stage angle-closure glaucoma. It is a safe method for early examination after operation.
ABSTRACT
Objective: To evaluate the effect of subconjunctival injection of Bevacizumab (Avastin) on corneal neovascularization(CNV) in rabbits. Methods: Forty-eight New Zealand rabbits were randomly divided into three groups: normal control group (group A, 3 rabbits), neovascularization group (group B, 9 rabbits) and Bevacizumab treatment group (group C, 36 rabbits). Group C was further divided into group C1 (1 day small dose group), C2 (1 day high dose group), C3 (14 days small dose group) and C4 (14 days high dose group), with 9 rabbits each group. CNV model was made by suture in group B and C. Animals in group C were injected subconjunctivally with 0.1 ml or 0.2 ml Bevacizumab (25 mg/ml) in the left eyes. The growth of CNV was observed every day after operation and the neovascularization areas calculated. Expression of VEGF in the cornea was detected by immunohistochemistry on day 7, 14 and 28 after suture. VEGF content in the aqueous humor was determined by ELISA assay. Results: CNV growth in group C1 and C2 was inhibited significantly compared with that in group B on day 7, 14 and 28 (P<0.01). On day 28 the growth in group C3 and C4 was significantly inhibited compared with that in group B (P<0.01), that in group C1 was significantly inhibited than that in group C3, and that in group C2 was significantly inhibited compared with that in group C4 (P<0.01). VEGF levels in the cornea and aqueous humor in group B increased as time passed by, and they were positively associated with CNV area (P<0.01). On day 7, 14, and 28, the VEGF levels in the cornea and aqueous humor in C1 and C2 groups were significantly lower than that in group B (P<0.01). On day 28, those in group C3 and C4 were significantly lower than those in group B (P<0.01); those in group C1 were significantly lower than those in group C3 (P<0.01); and those in group C2 were significantly lower than those in group C4 (P<0.01). The CNV area and VEGF levels in the cornea and aqueou humor were similar between C1 and C2 groups and between C3 and C4 groups. Conclusion: Subconjunctival administration of Bevacizumab can effectively inhibit corneal neovascularization in experimental CNV model, and early administration has a better outcome than late administration. Bevacizumab may exert its effect by down-regulating VEGF in cornea and aqueous humor.
ABSTRACT
Objective:To observe the changes in the anatomy of anterior segment before and after phacoemulsification for treatment of angle-closure glaucoma by Pentacam system,so as to assess the efficacy of phacoemulsification combined with artificial lens implantation(ALI)in treatment of early-and middle-stage angle-closure glaucoma.Methods:Forty-two patients with early-and middle-stage angle-closure glaucoma(44 eyes)were included in the present study.The central anterior chamber depth,anterior chamber volume and peripheral anterior chamber angle were examined by Pentacam system pre-operatively and 1 day,1 week and 3 months post operatively.Meanwhile,A ultrasound was used to examine the anterior chamber depth before and 3 months after operation.and the results were compared with those by Pentacam system.Results:Pentacam system could clearly demonstrate the 3-dimensional structures of the anterior eye segment before and after operation.The central anterior chamber depth,anterior chamber volume and anterior chamber angle were increased significantly after operation(P